Greeting

Curriculum Vitae of Professor Takayoshi Nakano

Name: Takayoshi NAKANO
Date of Birth: 22nd September 1967
Place of Birth: Okayama, Japan
Nationality: Japanese
Sex: Male

Office Address: Division of Materials & Manufacturing Science,
Graduate School of Engineering, Osaka University
2-1, Yamadaoka, Suita, Osaka, 565-0871, Japan
TEL: +81-(0)6-6879-7505
FAX: +81-(0)6-6879-7505
E-mail: nakano@mat.eng.osaka-u.ac.jp

Present Position:
2008- Professor of Division of Materials and Manufacturing Science,
Graduate School of Engineering, Osaka University, Osaka, Japan

Education and Degrees:

1986-1990	School of Engineering, Osaka University
1990-1992	Graduate School of Engineering, Osaka University
1996	Ph.D. (Osaka University, Engineering)

 

Previous Work Experience:

1992-1999	Assistant Professor, Department of Materials Science and Engineering, Faculty of Engineering, Osaka University, Osaka, Japan
1999-2008	Associate Professor, Division of Materials and Manufacturing Science, Graduate School of Engineering, Osaka University, Osaka, Japan
2008-	Professor, Division of Materials and Manufacturing Science, Graduate School of Engineering, Osaka University, Osaka, Japan
2008-	Professor, Global Center for Medical Engineering and Informatics, Osaka University, Osaka, Japan
2008-	Professor, Education and Research Center for Advanced Structural and Functional Materials Design, Osaka University, Osaka, Japan
2014-	Vice Director and Professor, Osaka University Anisotropic Design and AM Research Center, Osaka, Japan
2017-	Distinguished Professor, Osaka University, Osaka, Japan

 

Member of Scientific and Professional Organization
International Union of Societies for Biomaterials Science and Engineering (Fellow, Biomaterials Science and Engineering)
The Japan Institute of Metals and Materials (Vice President)
Japanese Society for Biomaterials (Executive Director)
Japanese Society of Bone Morphometry (Executive Director)
The Japanese Society for Bone and Mineral Research (Board Member)
The Materials Research Society of Japan (Executive Director)

Serving as Reviewer for:
Acta Materialia, Acta Biomaterialia, Biomaterials, Scripta Materialia, International Journal of Metallurgical & Materials Engineering (Editorial Board), ISRN Metallurgy (Editorial Board)

Honors and Awards:
2020 Awards for Science and Technology (Research Category) (The Commendation for Science and Technology by the Minister of Education, Culture, Sports, Science and Technology)
2019 Academic Award of JSBMR (The Japanese Society for Bone and Mineral Research)
2019 The Japan Institute of Metals and Materials Tanikawa-Harris Award
2018 The Japan Institute of Metals and Materials Distinguished Achievement Award
2016 Award of Japanese Society for Biomaterials, Japanese Society for Biomaterials
2012 Japan Society for the Promotion of Science Award, Japan Society for the Promotion of Science
2007 The Japan Institute of Metals and Materials Meritorious Award, The Japan Institute of Metals and Materials
2006 Encouragement Award of Science, Japanese Society for Biomaterials
2005 The Japan Institute of Metals and Materials Murakami Young Researcher Award, The Japan Institute of Metals and Materials And more

Patents:
2016 Method for manufacturing structure and structure (Japan: 5918499)
2014 Method for manufacturing Co-Cr alloy single crystal for implant device and implant device (Japan: 5561690)
2012 Implant material and method for manufacturing implant material (Japan: 51536262)
2012 Method for evaluating hard tissue (Japan: 5150892)
2012 Device for controlling bone apatite orientation (Japan: 4997499)
2011 Shock absorbing structure and method of manufacturing same (Japan: 4802277, China: 1398110, Singapore: 175882) And more

Grants:

2018-2023	"Establishment of Anisotropic Materials Science for Bone regeneration", Grant-in-Aid for Scientific Research (S), from JSPS
2013-2021	"Bio-functionalization of Metallic Biomaterials", Medical Research and Development Programs Focused on Technology Transfer: Strategic Promotion of Innovative Research and Development (S-Innovation), from Japan Agency for Medical Research and Development (AMED)
2014-2019	"Establishment and Validation of the base for 3D Design & Additive Manufacturing Standing on the Concepts of “Anisotropy” & “Customization”", Cross-Ministerial Strategic Innovation Promotion Program (SIP), Innovative Design/Manufacturing Technologies, from the New Energy and Industrial Technology Development Organization (NEDO)
2013-2018	"Establishment of Materials Bone Biology for Induction of Oriented Bone Microstructure", Grant-in-Aid for Scientific Research (S), from JSPS
2015-2016	"Novel Metallic Bone Implants Recognized as Biological Bone Tissue Itself in Biological System", Grant-in-Aid for Challenging Exploratory Research, from the Japan Society for the Promotion of Science (JSPS)
2013-2015	"Prototyping of composite products with bone-mimetic mechanical functions based on novel functionalization concept", Grant-in-Aid for Challenging Exploratory Research, from JSPS
2013-2014	"Creation of Bone Replacement Materials Based on Mechanisms for Establishment of Oriented Bone Nano-structure", Grant-in-Aid for Scientific Research (A), from JSPS
2010-2014	"Hierarchically-Structured Implant Functioning for Individual Patients", the Programs of Special Coordination Funds for Promoting Science and Technology, from the Ministry of Education, Culture, Sports, Science, and Technology (MEXT) of Japan
2011-2013	"Bone Biomaterials Developed by Bone Microstructure", Funding Program for Next Generation World-Leading Researchers (NEXT Program), from JSPS
2009-2011	"Induction of Bone with Oriented Structure based on Materials Science of Anisotropy", Grant-in-Aid for Encouragement of Young Scientists (S), from JSPS
2009-2009	"Creation of Powder/Solid Composite Structure Possessing Bone Mimetic Mechanical Functions", Grant-in-Aid for Challenging Exploratory Research, from JSPS
2009-2009	"Design and Development of Novel Biomaterials based on Anisotropically Arranged Bone Microstructure", Grant-in-Aid for Scientific Research (A), from JSPS
2007-2008	"Establishment of Materials Bone Biology", Grant-in-Aid for Exploratory Research, from JSPS
2007-2008	"Mechanism for Formation of Preferential Alignment in Bone Microstructure", Grant-in-Aid for Scientific Research (B), from JSPS
2005-2006	"Development of Method for Rapid Bone Regeneration Utilizing Strong Magnetic Field and Bone Analyses Based on Materials Scientific Technologies", Grant-in-Aid for Encouragement of Young Scientists (A), from JSPS

And more...

Current Work and Specialization:

From 2008, I have been Professor of Division of Materials and Manufacturing Science, Graduate School of Engineering, Osaka University. My major tasks are: taking responsibility for running my laboratory (Biomaterials and Structural Materials Area); giving lectures for undergraduate and graduate student; supervising postgraduate students’ research; conducting my own researches based on Materials Science of Anisotropy (see below for details).

Highlights of Leading Recent Specific Research Projects:
・Analyses of Bone Microstructural Anisotropy and Control of ECM Orientation in vivo
Anisotropy in bone microstructure mainly consisting of biological apatite and collagen type-I has been clarified to be relating the anisotropic mechanical functions, which is important for bone tissues to mechanically function under anisotropic mechanical fields. This indicates that in vivo mechanical field is one of controlling factors of anisotropic arrangement of apatite/ collagen. Indeed, we succeeded in controlling apatite/collagen orientation by artificially imposing abnormal of mechanical field (e.g., magnitude and direction of principal stress). In addition, oriented microstructure was greatly affected by metabolic conditions, therefore, pathologic bones showed disordered microstructures. We are trying to elucidate the mechanism of bone pathology from the microstructural viewpoint and regain sound bone microstructure by using medications as well as external fields.
Published in Bone (2002, 2012, 2015, 2018, 2019), Journal of Bone and Mineral Research (2013), Journal of the American Society of Nephrology (2014), Tissue Engineering, Part C (2016), Calcified Tissue International (2016), and Bone and Mineral Metabolism (2016×2)
・Clarification of Mechanisms for Formation of Preferential alignment of Cell and ECM
Control of cell alignment is one of the targets for arranging the anisotropic extracellular matrix (ECM) of tissue. We have been trying to control cellular alignment and clarify the mechanisms for the formation of ECM alignment using cell cultivation. Importantly, we successfully revealed that the bone matrix anisotropy is quantitatively controllable by varying the degree of osteoblast alignment via regulating the level of substrate orientation. In addition, the characteristic organization of a collagen/apatite composite orthogonal to the osteoblast orientation along a nanometer-scale periodic geometry was found for the first time. The obtained findings indicate that the bone tissue anisotropy is controllable, including the preferred direction and degree of apatite orientation, by regulating the osteoblast arrangement using surface modification of biomaterials. The studies for clarifying biological factors involving in the regulation of cell and ECM alignment are on-going.
Published in Biomaterials (2012, 2015, 2019), Acta Biomaterialia (2013), Journal of Biomedical Materials Research Part A (2015), and Crystals (2016)
・Creation of Novel Implant Materials Promoting Bone Health
One of big challenges in oral and orthopedic implantology is preventing stress shielding phenomena (removal of sound mechanical stimuli for maintain bone healthy) which induce increased fracture risk owing to bone loss and degraded bone quality. To overcome this problem, we are developing novel implants with two strategies: one is reducing Young’s modulus of implant materials; the other is enhancing stress transmission via bone-implant interface by introducing specific pore structure, for example, grooves. Usage of additive manufacturing technology might be quite effective for realizing implant devises with both low Young’s modulus and surface structures.
Published in ISIJ International (2011), Bone (2013), Metallurgical and Materials Transactions A (2014), Acta Biomaterialia (2016), Scientific Reports (2016), and Implant Dentistry (2016)

Research papers:
Original article: 370, Conference Paper: 68, Book: 48, Review: 193
・UVA-activated riboflavin promotes collagen crosslinking to prevent root caries, Scientific Reports, 9, (2019) paper#1252.
Osteoporosis changes collagen/apatite orientation and Young’s modulus in vertebral cortical bone of rat, Calcified Tissue International, 104, (2019), 449-460.
・Unique arrangement of bone matrix orthogonal to osteoblast alignment controlled by Tspan11-mediated focal adhesion assembly, Biomaterials, 209 (2019), 103-110
・Quantitative ultrasound (QUS) axial transmission method reflects anisotropy in micro-arrangement of apatite crystallites in human long bones: A study with 3-MHz-frequency ultrasound, Bone, 127 (2019), 82-90.
・Development of Non-equiatomic Ti-Nb-Ta-Zr-Mo High-Entropy Alloys for Metallic Biomaterials, Scripta Materialia, 172 (2019), 83-87.
Effects of long-term cigarette smoke exposure on bone metabolism, structure, and quality in a mouse model of emphysema, PLoS ONE, 13 (2018), e0191611.
・Effect of scanning strategy on texture formation in Ni-25 at.%Mo alloys fabricated by selective laser melting, Materials & Design, 140 (2018), pp.307-316.
・Plastic deformation mechanisms of biomedical Co-Cr-Mo alloy single crystals with hexagonal close-packed structure, Scripta Materialia, 142 (2018), pp.111-115.
・Influence of unique layered microstructure on fatigue properties of Ti-48Al2Cr-2Nb alloys fabricated by electron beam melting, Intermetallics, 95 (2018), 1-10.
・Microstructure of equiatomic and non-equiatomic Ti-Nb-Ta-Zr-Mo high-entropy alloys for metallic biomaterials, Journal of Alloys and Compounds, 753 (2018), 412-421.
・Dual release of growth factor from a nanocomposite fibrous scaffold promotes vascularisation and bone regeneration in a rat critical sized calvarial defect, Acta Biomaterialia, 78 (2018), 36-47.
・Excellent mechanical and corrosion properties of austenitic stainless steel with a unique crystallographic lamellar microstructure via selective laser melting, Scripta Materialia, 159 (2018), 89-93.
・Beta titanium single crystal with bone-like elastic modulus and large crystallographic elastic anisotropy, Journal of Alloys and Compounds, 782 (2018), 1-17.
・Co-deteriorations of anisotropic extracellular matrix arrangement and intrinsic mechanical property in c-src deficient osteopetrotic mouse femur, Bone, 103 (2017), 216-223.
・Optimally oriented grooves on dental implants improves bone quality around implants under repetitive mechanical loading, Acta Biomaterialia, 48 (2017), 433-444.
・Unloading-induced degradation of the anisotropic arrangement of collagen/apatite in rat femurs, Calcified Tissue International, 100 (2017), 87-97.
・Isotropic plasticity of β-type Ti-29Nb-13Ta-4.6Zr alloy single crystals for the development of single crystalline β-Ti implants, Scientific Reports, 6 (2016), srep29779.
・Altered material properties are responsible for bone fragility in rats with chronic kidney injury, Bone, 81 (2015), 247-254.
Combination of BMP-2-releasing gelatin/β-TCP sponges with autologous bone marrow for bone, regeneration of X-ray-irradiated rabbit ulnar defects, Biomaterials, 56 (2015), 18-25.
・Novel powder/solid composites possessing low Young’s modulus and tunable energy absorption capacity, fabricated by electron beam melting, for biomedical applications, Journal of Alloys and Compounds, 639 (2015), 336-340.
・Abnormal arrangement of a collagen/apatite extracellular matrix orthogonal to osteoblast alignment is constructed by a nanoscale periodic surface structure, Biomaterials, 37 (2015), 134-143.
・Structural and qualitative bone remodeling around repetitive loaded implants in rabbits, Clinical Implant Dentistry and Related Research, 12 (2015), e699-e710.
・Degradation behavior of Ca-Mg-Zn intermetallic compounds for use as biodegradable implant materials, Materials Science and Eigineering C, 44 (2014), 285-292.
・Continuous cyclic stretch induces osteoblast alignment and formation of anisotropic collagen fiber matrix, Acta Biomaterialia, 9 (2013), 7227-7235.
・Degree of biological apatite c-axis orientation rather than bone mineral density controls mechanical function in bone regenerated using rBMP-2, Journal of Bone and Mineral Research, 28 (2013), 1170-1179.
・Design and optimization of the oriented groove on the hip implant surface to promote bone microstructure integrity, Bone, 52 (2013), 659-667.
・Mesenchymal stromal cells improve the osteogenic capabilities of mineralized agarose gels in a rat full-thickness cranial defect model, Journal of Tissue Engineering and Regenerative Medicine, 7 (2013), 51-60.
・Biological apatite (BAp) crystallographic orientation and texture as a new index for assessing the microstructure and function of bone regenerated by tissue engineering, Bone 51 (2012), 741-747.
・The alignment of MC3T3-E1 osteoblasts on steps of slip traces introduced by dislocation motion, Biomaterials, 33 (2012), 7327-7335. And more...