What's New
2016（January－June）
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2016.6.25
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2016.6.23
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2016.6.8
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2016.5.28
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2016.4.19
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2016.3.31
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2016.3.24
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2016.3.23
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2016.3.5
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2016.3.3
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2016.2.10
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2016.2.8
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2016.2.1
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2016.1.22
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2016.6.25
Mr. Sekita (D3) received the Young Researcher Award at the 36th Annual Meeting of Japanese Society For Bone Morphometry.
Aiko Sekita, Aira Matsugaki, Takayoshi Nakano:
Reduced bone orientation and its effect on bone mechanical function in a mouse model of osteogenic cancer bone metastasis
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2016.6.23
A paper on controlling cell orientation by surface undulation through deformation was published in Crystals.
Aira Matsugaki, Takayoshi Nakano:
Control of cellular arrangement by surface topography induced by plastic deformation,
Crystals, 6(6), (2016), 73（Open access journal）, on line
DOI:10.3390/cryst6060073Click here for this paper.
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2016.6.8
Our collaborative research with Dr. Imazato of the Graduate School of Dentistry has been published in Dental Materials Journal.
Hiroyuki Miyajima, Takuya Ishimoto, Sai MA, Jihua Chen, Takayoshi Nakano and Satoshi Imazato:
In vitro assessment of a calcium-fluoroaluminosilicate glass-based desensitizer for the prevention of root surface demineralization,
Dental Materials Journal, (2016), 35(3), pp.399–407. -
2016.5.28
Received a poster award at The Japan Institute of Light Metals.
Kentaro Ishii, Koji Hagiwara, Takayoshi Nakano:
Creation of multiphase alloys of soluble compounds in the Ca-Mg-Zn system,
Japan Institute of Light Metals Spring Meeting, Poster Award (2016) -
2016.4.19
A paper on our collaborative research with Hagiwara Lab. was published in "Materials Letters".
Koji Hagihara, Koretaka Yuge, Takaaki Ikenishi, Haruka Araki, and Takayoshi Nakano:
Effect of additional elements on fracture toughness of (Mo0.85Nb0.15)Si2 C40/C11b lamellar-structured crystals,
Materials Letters, (2016), in press. -
2016.3.31
A study on changes in inferior bone orientation in osteoarthritis has been published in the Journal of Bone and Mineral Metabolism (JBMM).
Jee-Wook Lee, Akio Kobayashi, Takayoshi Nakano:
Crystallographic orientation of the c-axis of biological apatite as a new index
of the quality of subchondral bone in knee joint osteoarthritis,
Bone and Mineral Metabolism (JBMM), (2016), on line.
DOI: 10.1007/s00774-016-0754-yAbstract
The aim of the present study was to investigate the preferred orientation of biological apatite (BAp) as a new index of the quality of subchondral bone (SB) in knee joint osteoarthritis (OA). Ten OA and five normal knee joints were obtained. Thickness, quantity and bone mineral density (BMD) of SB were analyzed at the medial condyle of the femur in dry conditions by peripheral quantitative computed tomography. In addition, the preferred crystallographic orientation of the c-axis of BAp was evaluated as bone quality parameter using a microbeam X-ray diffractometer technique. BMD and thickness of SB were significantly increased in OA specimens compared to normal knee specimens (P < 0.01), and the preferred orientation of the c-axis of BAp along the normal direction of SB surface was significantly higher in OA specimens (P < 0.01), reflecting the change in stress of concentration in the pathological portion without cartilage. SB sclerosis in OA results in both proliferation of bone tissues and enhanced degree of preferential alignment of the c-axis of BAp. Our findings could have major implications for the diagnosis of clinical studies, including pathologic elucidation in OA. -
2016.3.24
A collaborative research with Hagiwara Lab. won the Best Poster Award at the 26th Japan Institute of Metals.
〇Takaaki Ikenishi, Haruka Araki, Koji Hagiwara, Takayoshi Nakano:
Mechanical properties of Cr and Ir co-doped NbSi2/MoSi2 multiphase silicide -
2016.3.23
Dr. Hagiwara and Dr. Inamura received The Japan Institute of Metals and Materials Meritorious Award, which is a gateway to success in the Japan Institute of Metals and Materials.
Dr. Hagiwara and Dr. Inamura received The Japan Institute of Metals and Materials Meritorious Award, which is a gateway to success in the Japan Institute of Metals and Materials.
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2016.3.5
Our collaborative paper with Hagiwara Lab has been published in Acta Materialia.
Koji Hagihara, Takuya Okamoto, Hitoshi Izuno, Michiaki Yamasaki, Masafumi Matsushita, Takayoshi Nakano, Yoshihito Kawamura:
Plastic deformation behavior of 10H-type synchronized LPSO phase in a Mg-Zn-Y system,
Acta Materialia, 109 (2016), pp.90-102. -
2016.3.3
Our collaborative paper with Hagiwara Lab. was published in the journal "Scripta Materialia".
Koji Hagihara, Takuya Okamoto, Michiaki Yamasaki, Yoshihito Kawamura, Takayoshi Nakano:
Electron backscatter diffraction pattern analysis of the deformation band formed in the Mg-based long-period stacking ordered phase,
Scripta Materialia, 117 (2016), pp.32-36.Abstract
A newly proposed analysis protocol using electron backscatter diffraction pattern analysis in scanning electron microscopy (SEM-EBSD) clarified that the deformation bands formed in the Mg-based long-period stacking ordered (LPSO) phase are predominantly deformation kink bands. The kink band contains many additional boundaries within it, and the coalescence of these boundaries varies the crystal rotation angle and rotation axis at the kink band boundaries during their development. The reason for the appearance of a “beak-like” shape in deformation kink band in the LPSO phase was clarified by proposing a unique three-dimensional morphology. -
2016.2.10
Collaborative research on two-phase layered silicide with Hagiwara Lab. was published in "Acta Materialia".
Koji Hagihara, Haruka Araki, Takaaki Ikenishi, Takayoshi Nakano:
Creep-deformation behavior of (Mo0.85Nb0.15)Si2 lamellar-structured C40/C11b two-phase crystals,
Acta Materialia, 107 (2016), pp.196-212.Abstract
The creep-deformation behavior of (Mo0.85Nb0.15)Si2 crystals that were composed of C40 and C11b two-phases with an oriented lamellar microstructure was examined over 1200–1400 °C under compression. The creep behavior of the crystals varied greatly depending on the orientation of the loading axis with respect to the lamellar interfaces. The steady-state creep strain rate (SSCR) when the loading orientation was parallel to the lamellar interfaces (0°-orientation) was approximately 2 orders of magnitude lower than that when the loading orientation was inclined by 45° (45°-orientation). Creep tests were performed also with single crystals of C40-single-phase (Mo0.85Nb0.15)Si2, and proved that the C40-phase effectively acts as a strengthening phase in the creep behavior of the C40/C11b duplex-phase crystals. The variant-1-type C11b phase grains, which have a loading orientation parallel to [001], were also found to act as an effective strengthening component. The SSCR of the 0°-orientation was succeeded to be further decreased by controlling the lamellar microstructure via the addition of Cr. The SSCR of the 1 at.%-Cr-added lamellar-structured crystal under 300 MPa in the 0°-orientation was approximately a third of that of the non-added ternary crystal. -
2016.2.8
An article about our laboratory was published in THE BONE.
Aira Matsugaki, Takayoshi Nakano: Regulation of cell alignment for the construction of anisotropic bone matrix
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2016.2.1
Dr. Matsugaki's commentary article appeared in Matelia Vol. 55 "Habataku".
Aira Matsugaki:
Challenge to "Life Phenomena",
Matelia, Vol.55 [2] (2016), pp.74.Click here for this commentary.
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2016.1.22
A paper on our collaborative research with Osaka University School of Dentistry and The Jikei University of Tokyo has been published in Scientific Reports, a publication of "nature".
T. Shinno, T. Ishimoto, M. Saito, R. Uemura, M. Arino, K. Marumo, T. Nakano, M. Hayashi:
Comprehensive analyses of how tubule occulusion and advanced glycation end-products diminish
strength of aged dentin,
Scientific Reports, (2015), srep19849.
DOI:10.1038/srep19849Abstract
In clinical dentistry, since fracture is a major cause of tooth loss, better understanding of mechanical properties of teeth structures is important. Dentin, the major hard tissue of teeth, has similar composition to bone. In this study, we investigated the mechanical properties of human dentin not only in terms of mineral density but also using structural and quality parameters as recently accepted in evaluating bone strength. Aged crown and root dentin (age ≥ 40) exhibited significantly lower flexural strength and toughness than young dentin (age < 40). Aged dentin, in which the dentinal tubules were occluded with calcified material, recorded the highest mineral density; but showed significantly lower flexural strength than young dentin. Dentin with strong alignment of the c-axis in hydroxyapatite exhibited high fracture strength, possibly because the aligned apatite along the collagen fibrils may reinforce the intertubular dentin. Aged dentin, showing a high advanced glycation end-products (AGEs) level in its collagen, recorded low flexural strength. We first comprehensively identified significant factors, which affected the inferior mechanical properties of aged dentin. The low mechanical strength of aged dentin is caused by the high mineral density resulting from occlusion of dentinal tubules and accumulation of AGEs in dentin collagen