What's New
2019（January－June）
-
2019.6.21
-
2019.6.17
-
2019.6.17
-
2019.6.6
-
2019.5.29
-
2019.5.18
-
2019.5.13
-
2019.5.11
-
2019.4.27
-
2019.4.26
-
2019.4.24
-
2019.4.18
-
2019.4.17
-
2019.4.17
-
2019.4.1
-
2019.3.20
-
2019.3.13
-
2019.3.6
-
2019.3.1
-
2019.2.28
-
2019.2.27
-
2019.2.4
-
2019.2.1
-
2019.1.31
-
2019.1.30
-
2019.1.25
-
2019.1.25
-
2019.1.21
-
2019.1.16
-
2019.1.11
-
2019.1.10
-
2019.1.4
-
2019.6.21
An article about the identification of the sequence factor of bone matrix in Nakano Laboratory was published in Nikkan Kogyo Shimbun.
Identifying sequence factors of bone matrix,
The Nikkan Kogyo Shimbun (page 29: Science, Technology and Universities), June 21, 2019.Click here for this article.
-
2019.6.17
An article about our laboratory will be published in the July issue of Modern Chemistry.
Aira Matsugaki, Takayoshi Nakano:
Stress-Induced Bone Remodeling - Surface Morphology that Promotes Bone Orientation and Bone Regeneration,
Gendai Kagaku July, (No.580), Tokyo Kagaku Doujin, (2019), pp.56-59.Click here for this PDF.
-
2019.6.17
The article about the device for the method of "measuring bone orientation by ultrasound" with Nakano Lab. and Furuno Denki et al. appeared in the morning edition of the Nihon Keizai Shimbun.
Osaka University to use ultrasound to measure bone health,
Nihon Keizai Shimbun, Morning Edition (page 9: Science and Technology), June 17, 2019.Click here for this article.
-
2019.6.6
A paper that showed that apatite orientation as a bone quality parameter can be analyzed by a non-invasive method using ultrasound for human bones has been published in Bone as an open-access journal.
Takuya Ishimoto, Ryoichi Suetoshi, Dorian Cretin, Koji Hagihara, Jun Hashimoto, Akio Kobayashi, Takayoshi Nakano*:
Quantitative ultrasound (QUS) axial transmission method reflects anisotropy in micro-arrangement of apatite crystallites in human long bones: A study with 3-MHz-frequency ultrasound,Bone, 127, (2019), 82-90
https://doi.org/10.1016/j.bone.2019.05.034.
Abstract
Anisotropic arrangement of apatite crystallites, i.e., preferential orientation of the apatite c-axis, is known to be an important bone quality parameter that governs the mechanical properties. However, noninvasive evaluation of apatite orientation has not been achieved to date. The present paper reports the potential of quantitative ultrasound (QUS) for noninvasive evaluation of the degree of apatite orientation in human bone for the first time. A novel QUS instrument for implementation of the axial transmission (AT) method is developed, so as to achieve precise measurement of the speed of sound (SOS) in the cortex (cSOS) of human long bone. The advantages of our QUS instrument are the following: (i) it is equipped with a cortical bone surface-morphology detection system to correct the ultrasound transmission distance, which should be necessary for AT measurement of long bone covered by soft tissue of non-uniform thickness; and (ii) ultrasound with a relatively high frequency of 3 MHz is employed, enabling thickness-independent cSOS measurement even for the thin cortex by preventing guide wave generation. The reliability of the proposed AT measurement system is confirmed through comparison with the well-established direct transmission (DT) method. The cSOS in human long bone is found to exhibit considerable direction-dependent anisotropy; the axial cSOS (3870 ± 66 m/s) is the highest, followed by the tangential (3411 ± 94 m/s) and radial (3320 ± 85 m/s) cSOSs. The degree of apatite orientation exhibits the same order, despite the unchanged bone mineral density. Multiple regression analysis reveals that the cSOS of human long bone strongly reflects the apatite orientation. The cSOS determined by the AT method is positively correlated with that determined by the DT method and sensitively reflects the apatite orientation variation, indicating the validity of the AT instrument developed in this study. Our instrument will be beneficial for noninvasive evaluation of the material integrity of the human long-bone cortex, as determined by apatite c-axis orientation along the axial direction.Click here for this paper.
-
2019.5.29
"Biocompatibility of Inorganic/Organic Materials by Surface Treatment and Modification", which Nakano Lab. contributed to, has been published by CMC Publishing.
Ryosuke Kozasa, Takuya Ishimoto, Takayoshi Nakano ( shared authorship):
Microstructure Formation and Orientation Control by Adding Anisotropy to Biomedical Metallic Materials,
Biocompatibility by Surface Treatment and Modification of Inorganic/Organic Materials (supervised by Yuji Haisima), CMC Publishing, (2019).Click here for more details.
-
2019.5.18
"Metals for Biomedical Devices - Second Edition (Edited by M. Niinomi)", which Dr. Nakano contributed to, has been published by Elsevier (Woodhead Publishing).
Dr. Nakano was in charge of "Part 2: Mechanical behavior, degradation, and testing of metals for biomedical devices", and wrote about the basics of mechanical functions related to additive manufacturing and the creation of new metallic medical devices considering the anisotropy of bone.
Takayoshi Nakano (Collected written):
Mechanical behavior, degradation, and testing of metals for biomedical devices, Metals for Biomedical Devices –Second Edition (Edited by M. Niinomi),
Elsevier (Woodhead Publishing), (2019) pp.97-126.Table of Contents
Part 2: Mechanical behavior, degradation, and testing of metals for biomedical devices
3 Physical and mechanical properties of metallic biomaterials 97
3.1 Introduction 97
3.2 Metallic biomaterials which can realize sufficient mechanical
properties for use in vivo 97
3.3 Methods for strengthening metallic biomaterials 110
3.4 Phase rule and phase diagram 111
3.5 Deformation and recovery, recrystallization, and grain
ripening 114
3.6 Microstructure and related mechanical properties in typical metallic
biomaterials 115
3.7 Development of metallic biomaterials based on biological bone
tissues 116
3.8 Additive manufacturing technology for developing metallic
biomaterials 121
3.9 Summary 126
Acknowledgments 126
References 126Click here for more details.
-
2019.5.13
Nakano Lab's commentary and paper were published in the May issue of "The Journal of Smart Process Society for Materials, Environment & Energy".
Hiroyuki Yasuda, Ken Zhao, Mitsuharu Todai, Takayoshi Nakano, Minoru Ueda, Daisuke Kondo, Shotaro Karato, Ayako Ikeda, and Masao Takeyama:
Microstructure Control and Mechanical Properties of TiAl Intermetallic Compound by Additive Manufacturing Process,
The Journal of Smart Process Society for Materials, Environment & Energy, 8 [3], "Development of Innovative Hard Materials Opened by Additive Manufacturing Process (1)", (2019), pp.78-83.Koji Hagiwara, Takuya Ishimoto, Shihai Sun, and Takayoshi Nakano:
Crystal orientation and microstructure control of silicide intermetallic compounds by additive manufacturing process,.
The Journal of Smart Process Society for Materials, Environment & Energy, 8 [3], "Development of Innovative Hard Materials Opened by Additive Manufacturing Process (1)", (2019), pp.84-89.Hiroki Amano, Tomoaki Sasaki, Yuji Nomura, Takuya Ishimoto, Takayoshi Nakano:
An Effect of Oxygen in Atmosphere on Spatter Generation in Laser Additive Manufacturing.
The Journal of Smart Process Society for Materials, Environment & Energy, 8 [3], "Development of Innovative Hard Materials Opened by Additive Manufacturing Process (1)", (2019), pp.102-105.Ryutaro Okada, Yoshimichi Nomura, Kenichiro Igashira, Takayoshi Nakano:
Anisotropic microstructure control for improving creep properties of Ni-based superalloy by additive manufacturing process,.
The Journal of Smart Process Society for Materials, Environment & Energy, 8 [3], "Development of Innovative Hard Materials Opened by Additive Manufacturing Process (1)", (2019), pp.106-111 . -
2019.5.11
The research results on the solidification structure of MEA (medium-entropy alloy) and HEA (high-entropy alloy) with TiNbTaZr as the basic composition were published as an open access article in Entropy of MDPI.
Takeshi Nagase, Kiyoshi Mizuuchi, Takayoshi Nakano*:
Solidification microstructures of the ingots obtained by arc-melting and cold crucible levitation melting in an equiatomic TiNbTaZr medium-entropy alloy and TiNbTaZrX (X = V, Mo, W) high-entropy alloys,
Entropy, 21(5), (2019) pp.483: 1-17Abstract
The solidification microstructures of the TiNbTaZr medium-entropy alloy and TiNbTaZrX (X = V, Mo, and W) high-entropy alloys (HEAs), including the TiNbTaZrMo bio-HEA, were investigated. Equiaxed dendrite structures were observed in the ingots that were prepared by arc melting, regardless of the position of the ingots and the alloy system. In addition, no significant difference in the solidification microstructure was observed in TiZrNbTaMo bio-HEAs between the arc-melted (AM) ingots and cold crucible levitation melted (CCLM) ingots. A cold shut was observed in the AM ingots, but not in the CCLM ingots. The interdendrite regions tended to be enriched in Ti and Zr in the TiNbTaZr MEA and TiNbTaZrX (X = V, Mo, and W) HEAs. The distribution coefficients during solidification, which were estimated by thermodynamic calculations, could explain the distribution of the constituent elements in the dendrite and interdendrite regions. The thermodynamic calculations indicated that an increase in the concentration of the low melting-temperature V (2183 K) leads to a monotonic decrease in the liquidus temperature (TL), and that increases in the concentration of high melting-temperature Mo (2896 K) and W (3695 K) lead to a monotonic increase in TL in TiNbTaZrXx (X = V, Mo, and W) (x = 0 − 2) HEAs.
Click here for this PDF.
-
2019.4.27
A collaborative study with Dr. Niinomi on the quantitative and qualitative relationship between microstructure factors and fatigue life of Ti alloys under controlled loading and strain conditions has been published early in Materials Transactions.
M. Niinomi, T. Akahori, M. Nakai, Y. Koizumi, A. Chiba, T. Nakano, T. Kakeshita, Y. Yamabe-Mitarai, S. Kuroda, N. Motohashi, Y. Itsumi, T. Choda:
Quantitative and Qualitative Relationship between Microstructural Factors and Fatigue Lives under Load- and Strain-Controlled Conditions of Ti–5Al–2Sn–2Zr–4Cr–4Mo (Ti-17) Fabricated Using a 1500-ton Forging Simulator,
Materials Transactions, (2019),
DOI:10.2320/matertrans.ME201904Click here for this paper.
-
2019.4.26
Dr. Ozasa's article on Calcified Tissue International is now available on the 1st Author page of the Japan Society for Bone and Mineral Research website.
Ryosuke Ozasa, Takuya Ishimoto, Sayaka Miyabe, Jun Hashimoto, Makoto Hirao, Hideki Yoshikawa, Takayoshi Nakano*:
Osteoporosis changes collagen/apatite orientation and Young’s modulus in vertebral cortical bone of rat,
Calcified Tissue International, 104 [4], (2019), pp.449-460.
DOI:10.1007/s00223-018-0508-zClick here for this access.
-
2019.4.24
A paper on the successful fabrication of Ti-based alloys with crystal orientation in mixed powders by metal additive manufacturing has been published in Materials & Design as an open access journal.
Takeshi Nagase, Takao Hori, Mitsuharu Todai, Shi-Hai Sun, Takayoshi Nakano*:
Additive manufacturing of dense components in beta-titanium alloys with crystallographic texture from a mixture of pure metallic element powders,
Materials & Design, 173 [107771], (2019) pp.1-10
https://doi.org/10.1016/j.matdes.2019.107771Abstract
The fabrication of dense components composed of Ti-based alloys, i.e., Ti-X (X=Cr, Nb, Mo, Ta) alloys, from a mixture of pure elemental powders was achieved using selective laser melting (SLM) process. The Ti-Cr alloys comprise β-Ti single-phase components without any non-molten particles and macroscopic defects. The crystallographic texture of these β-Ti-Cr alloys can be controlled effectively by optimizing the build parameters. The development of {001}〈100〉crystallographic orientation during the SLM process is discussed based on the solidification process focusing on the columnar cell growth in the melt pool. These results demonstrate the possibility of fabricating the Ti-based alloy components with well-developed crystallographic texture from the mixture of pure elemental powders using the process of SLM.
Click here for this paper.
-
2019.4.18
Nakano Lab's collaborative research on titanium alloys has been published in a press release as "Tohoku University and Osaka University demonstrate the existence of a new phase transition called the "non-diffusion isothermal Omega transformation" and clar
-
2019.4.17
Research on the transformation mechanism of a new Ti alloy, conducted in collaboration with AIST and Tohoku University, was published in Physical Review Materials.
Masakazu Tane, Hiroki Nishiyama, Akihiro Umeda, Norihiko, L. Okamoto, Koji Inoue, Martin Luckabauer, Yasuyoshi Nagai, Tohru Sekino, Takayoshi Nakano, Tetsu Ichitsubo:
Diffusionless isothermal omega transformation in titanium alloys driven by quenched-in compositional fluctuations,
Physical Review Materials 3, 043604, (2019) pp.1-9.Click here for this paper.
-
2019.4.17
A paper finding that Tspan11 is one of the regulators of orthogonalized orientation substrates through cell arrangement has been published in Biomaterials (IF=8.8) as an open access journal.
Yohei Nakanishi, Aira Matsugaki, Kosuke Kawahara, Takafumi Ninomiya, Hiroshi Sawada, Takayoshi Nakano*:
Unique arrangement of bone matrix orthogonal to osteoblast alignment controlled by Tspan11-mediated focal adhesion assembly,
Biomaterials, 209, (2019) pp.103-110
DOI: https://doi.org/10.1016/j.biomaterials.2019.04.016Abstract
During tissue construction, cells coordinate extracellular matrix (ECM) assembly depending on the cellular arrangement. The traditional understanding of the relationship between the ECM and cells is limited to the orientation-matched interaction between them. Indeed, it is commonly accepted that the bone matrix (collagen/apatite) is formed along osteoblast orientation. Nonetheless, our recent findings are contrary to the above theory; osteoblasts on nanogrooves organize formation of the bone matrix perpendicular to cell orientation. However, the precise molecular mechanisms underlying the orthogonal organization of bone matrix are still unknown. Here, we show that mature fibrillar focal adhesions (FAs) facilitate the perpendicular arrangement between cells and bone matrix. The osteoblasts aligned along nanogrooves expressed highly mature fibrillar FAs mediated by integrin clustering. Microarray analysis revealed that Tspan11, a member of the transmembrane tetraspanin protein family, was upregulated in cells on the nanogrooved surface compared with that in cells on isotropic, flat, or rough surfaces. Tspan11 silencing significantly disrupted osteoblast alignment and further construction of aligned bone matrix orthogonal to cell orientation. Our results demonstrate that the unique bone matrix formation orthogonal to cell alignment is facilitated by FA maturation. To the best of our knowledge, this report is the first to show that FA assembly mediated by Tspan11 determines the direction of bone matrix organization.Click here for this paper.
-
2019.4.1
An article on the introduction of Additive Manufacturing technology focusing on titanium and titanium alloys appeared in Matelia.
Takayoshi Nakano, Takuya Ishimoto:
Additive Manufacturing Process of Titanium and Titanium Alloys,
Matelia, 58, [4], (2019),pp.181-187.Click here for this PDF.
-
2019.3.20
Dr. Nakano received The 58th Japan Institute of Metals and Materials Tanikawa-Harris Award at the 2019 (164th) Spring Meeting of the Japan Institute of Metals and Materials.
Takayoshi Nakano:
A Study on Plastic Behavior of Heat-Resistant Intermetallic Compounds Based on Anisotropy and Its Application to Biomaterials,
The 58th Japan Institute of Metals and Materials Tanikawa-Harris Award, The Japan Institute of Metals and Materials 2019 (164th) Spring Meeting, Tokyo Denki University, March 20, 2019. -
2019.3.13
The third article in Dr. Nakano's three-part series on metal 3D printers was published today in the Nikkan Kogyo Shimbun.
Design Sekkei, SIP Innovative Design and Manufacturing Technology, "Anisotropic Custom AM to Realize 'Material Revolution",
Nikkan Kogyo Shimbun, March 13, 2019, page 26, Science, Technology and University section.Click here for this article.
-
2019.3.6
The second of Dr. Nakano's three articles on metal 3D printers was published today in the Nikkan Kogyo Shimbun.
SIP Innovative Design and Manufacturing Technology, "Anisotropic Custom AM, Metal 3D Printer: Fixing Problem Areas During Molding",
The Nikkan Kogyo Shimbun, March 6, 2019, page 23, Science and Technology, University section.Click here for this article.
-
2019.3.1
Our paper on low elasticity of Ti-Nb base alloys by Cr addition has been published on line in Journal of Materials Science.
Qiang Li, Guanghao Ma, Junjie Li, Mitsuo Niinomi, Masaaki Nakai, Yuichro Koizumi, Dai-Xiu Wei, Tomoyuki Kakeshita, Takayoshi Nakano, Akihiko Chiba, Xuyan Liu, Kai Zhou, Deng Pan:
Development of low-Young’s modulus Ti–Nb-based alloys with Cr addition,
Journal of Materials Science,54, (2019),pp.8675-8683.
https://doi.org/10.1007/s10853-019-03457-0.Abstract
Different amounts of Cr were added to a metastable β-type Ti–22Nb (at.%) alloy to obtain desirable mechanical properties, including a low Young’s modulus, high strength, and good plasticity. The mechanical properties and microstructural changes were investigated. Cr has a high ability to stabilize the β phase, as well as suppress both α″ martensite and ω phase transformations during quenching and the stress-induced α″ martensite transformation during tension. Solid solution strengthening is scarcely achieved by Cr addition. The changes in mechanical properties can be attributed to the different β stabilities. The Ti–22Nb–(0,1)Cr alloys have metastable β phases and exhibit double yielding phenomena, indicating a stress-induced α″ martensite transformation. The Ti–22Nb–(2,3)Cr alloys with stable β phases exhibit distinct work hardening caused by a {332}β<113>β twinning, which also occurs in the Ti–22Nb–(0,1)Cr alloys, but not in the Ti–22Nb–4Cr alloy. Low Young’s moduli of approximately 60 GPa are obtained for the Ti–22Nb–(1,2)Cr alloys. The Ti–22Nb–2Cr alloy exhibits desirable properties for biomedical applications, including an ultimate tensile strength of approximately 600 MPa and elongation of approximately 20%.
Click here for this paper.
-
2019.2.28
Dr. Nakano, Dr. Ishimoto, and Dr. Todai participated in the drafting of the test method for evaluating the interface strength of medical coating films (JSME standard), which was published.
Takayoshi Nakano, Takuya Ishimoto, Mitsuharu Todai (Members of the drafting committee):
Test Method for Evaluation of Interfacial Strength of Medical Coating Films,
Japan Society of Mechanical Engineers (JSME), JSME S 019-2019, (Japan Society of Mechanical Engineers), February 28, 2019, Maruzen, pp. 1-67. -
2019.2.27
Dr. Nakano's article on "Construction and regional demonstration of 3D anisotropic customized design/additive manufacturing base", which is a part of the Strategic Innovation Program (SIP) Innovative Design and Manufacturing Technology, was published in t
SIP Innovative Design and Manufacturing Technology, "Anisotropic Custom AM, Metal 3D Printer Utilization, Imitating Nature "in the Necessary Direction",
Nikkan Kogyo Shimbun, February 27, 2019, page 26, Science, Technology and University section.Click here for this article.
-
2019.2.4
The results of a collaborative research paper with the Graduate School of Dentistry at Osaka University have been published as an open access journal in the journal "Scientific Reports" published by Nature.
R. Uemura, J. Miura, T. Ishimoto, K. Yagi, Y. Matsuda, M. Shimizu, T. Nakano & M. Hayashi:
UVA-activated riboflavin promotes collagen crosslinking to prevent root caries,
Scientific Reports, 9, (2019) paper#1252.Abstract
Root caries is an increasingly problem in aging societies with severe implications for the general health and wellbeing of large numbers of people. Strengthening type-I collagen, a major organic component of human dentin, has proved effective in preventing root caries. This study sought to determine whether exposure to riboflavin followed by UVA irradiation (RF/UVA) could promote additional collagen crosslinking, and thus improve the acid and enzymatic resistance of human dentin under simulated oral environments. If so, it could offer potential for treatment of the intractable problem of root caries. The greatest flexural strengths were found in dentin exposed to a 0.1% riboflavin solution for 1 minute followed by 1,600 mW/cm2 UVA irradiation for 10 minutes. Mineral loss and lesion depth were significantly lower in the RF/UVA group than in the control group. The microstructures of dentinal tubules and collagen networks after RF/UVA treatment retained their original forms after acidic and enzymatic degradation. In conclusion, RF/UVA treatment may be a new method for preventing root caries with promising prospects for clinical application. -
2019.2.1
Two commentary articles ("Microstructure Research Frontiers for Materials Development by Microscopy (11)" - Development of Microscopy for Materials Evaluation and Progress of Advanced Evaluation Methods) have been published in Matelia.
Takeshi Nagase, Kiyoshi Mizuuchi, Mitsuharu Todai, Takayoshi Nakano:
Solidification Structure of High-Entropy Alloys Consisting of Group 4, 5, and 6 Elements, which are Being Developed as Heat-Resistant Alloys and Biological Alloys,
Special Issue on Frontiers of Microstructure Research for Materials Development by Microscopy (11) - Development of Microscopy for Materials Evaluation and Advanced Evaluation Methods - Multiscale Observation Using SEM, Matelia, 58 [2] (2019).
Click here for this PDF.Koji Hagiwara, Takaaki Ikenishi, Takayoshi Nakano:
Lattice lamellar microstructure control of C40/C11b ultra-high temperature heat-resistant multi-phase silicide by co-doping Cr and Ir,
Special Issue on "Microstructure Research Frontline for Materials Development by Microscopy (11)" - Development of Microscopy for Materials Evaluation and Advanced Evaluation Methods - Multiscale Observation Using SEM, Matelia, 58 [2], (2019).
Click here for this PDF. -
2019.1.31
The collaborative research result with Dr. Takuya Matsumoto of Okayama University Graduate School of Medical and Dental Sciences has been published in "Journal of Biomedical Materials Research Part A" as an open access journal.
Yosuke Kunitomi, Emilio Satoshi Hara, Masahiro, Okada, Noriyuki Nagaoka, Takuo Kuboki, Takayoshi Nakano, Hiroshi Kamioka, Takuya Matsumoto:
Biomimetic mineralization using matrix vesicle nanofragments,
Journal of Biomedical Materials Research Part A, (2019),pp.1021-1030.
https://doi.org/10.1002/jbm.a.36618Abstract
In vitro synthesis of bone tissue has been paid attention in recent years; however, current methods to fabricate bone tissue are still ineffective due to some remaining gaps in the understanding of real in vivo bone formation process, and application of the knowledge in bone synthesis. Therefore, the objectives of this study were first, to perform a systematic and ultrastructural investigation of the initial mineral formation during intramembranous ossification of mouse calvaria from a material scientists’ viewpoint, and to develop novel mineralization methods based on the in vivo findings. First, the very initial mineral deposition was found to occur at embryonic day E14.0 in mouse calvaria. Analysis of the initial bone formation process showed that it involved the following distinct steps: collagen secretion, matrix vesicle (MV) release, MV mineralization, MV rupture and collagen fiber mineralization. Next, we performed in vitro mineralization experiments using MVs and hydrogel scaffolds. Intact MVs embedded in collagen gel did not mineralize, whereas, interestingly, MV nanofragments obtained by ultrasonication could promote rapid mineralization. These results indicate that mechanically ruptured MV membrane can be a promising material for in vitro bone tissue synthesis.
-
2019.1.30
Our paper on the development of bioactive glass/poly(lactic acid) composite, a new material to improve bone mass and quality, has been published in the Journal of Biomedical Materials Research Part A as an open access journal.
Sungho Lee, Aira Matsugaki, Toshihiro Kasuga, Takayoshi Nakano*:
Development of bifunctional oriented bioactive glass / poly(lactic acid) composite scaffolds to control osteoblast alignment and proliferation,
Journal of Biomedical Materials Research Part A, (2019),pp.1031-1041.
doi.org/10.1002/jbm.a.36619Abstract
During the bone regeneration process, the anisotropic microstructure of bone tissue (bone quality) recovers much later than bone mass (bone quantity), resulting in severe mechanical dysfunction in the bone. Hence, restoration of bone microstructure in parallel with bone mass is necessary for ideal bone tissue regeneration; for this, development of advanced bifunctional biomaterials, which control both the quality and quantity in regenerated bone, is required. We developed novel oriented bioactive glass / poly(lactic acid) composite scaffolds by introducing an effective methodology for controlling cell alignment and proliferation, which play important roles for achieving bone anisotropy and bone mass, respectively. Our strategy is to manipulate the cell alignment and proliferation by the morphological control of the scaffolds in combination with controlled ion release from bioactive glasses. We quantitatively controlled the morphology of fibermats containing bioactive glasses by electrospinning, which successfully induced cell alignment along the fibermats. Also, the substitution of CaO in Bioglass®(45S5) with MgO and SrO improved osteoblast proliferation, indicating that dissolved Mg2+ and Sr2+ ions promoted cell adhesion and proliferation. Our results indicate that the fibermats developed in this work are candidates for the scaffolds to bone tissue regeneration that enable recovery of both bone quality and bone quantity.
-
2019.1.25
The results of our laboratory's discovery that the collagen/apatite orientation changes in the opposite direction depending on osteoporosis factors was published in the Nikkan Kogyo Shimbun.
In postmenopausal osteoporosis caused by estrogen deficiency, the orientation in the direction of principal stress increases, while in nutritional osteoporosis caused by calcium and phosphorus deficiency, it decreases, both of which are abnormal conditions.
Click here for this article.
-
2019.1.25
[Press Release] The inauguration of a 3D printer industry-academia-government collaboration base in Kansai, in which Osaka University AM Center will participate as a core member, was announced by the Kinki Bureau of Economy, Trade and Industry and release
A new center will be established mainly in the Kansai region to promote collaboration among companies and universities engaged in research and development for the creation of next-generation 3D printers and to promote their practical use. The Center for Anisotropic Custom Design and AM R&D of Osaka University will play a central role in this project by utilizing the advanced knowledge of anisotropic manufacturing that it has accumulated so far.
Click here for this article.
-
2019.1.21
Mr. Iijima (M1) won a poster award at the 2nd Materials Science and Engineering Talk in 2008.
Yuka Iijima, Taketsugu Nagase, Akira Matsugaki, Takuya Ishimoto, Megumi Ameyama (Ritsumeikan Univ.), Takayoshi Nakano:
Alloy design of Ti-Zr-Hf-Co-Cr-Mo biological high-entropy alloys -
2019.1.16
The results of our joint research with Hagiwara Lab. won the Best Poster Award at the 2008 Kansai Section Young Researchers' and Graduate Students' Research Presentation Meeting of The Japan Institute of Light Metals.
Yuki Narimoto, Koji Hagiwara, Takayoshi Nakano, Michiaki Yamazaki, and Yoshito Kawamura:
Control of microstructure and mechanical properties through the kink zone in Mg-based LPSO phase,
The Japan Institute of Light Metals, Kansai Section, Osaka University, Jan. 16, 2019. -
2019.1.11
The Nikkan Kogyo Shimbun reported the discovery that the layered microstructure of austenitic stainless steel can be controlled by using the metal AM method, resulting in significant improvements in strength and corrosion resistance. This is the result of
Click here for this article.
-
2019.1.10
Our laboratory's commentary on bone metabolism and apatite orientation was published in the journal "Renal and Bone Metabolism".
Ryosuke Ozasa, Takuya Ishimoto, Takayoshi Nakano:
Bone metabolism and apatite orientation,
Special Issue on Uremia and Bone," Kidney and Bone Metabolism, 32 [1] (2019) pp. 45-50. -
2019.1.4
Dr. Nakano collaborated in writing the book, "Visual Understanding of Biomaterials, Revised 3rd Edition", published by Gakken Medical Shujunsha.
Takayoshi Nakano (Shared authorship).
Visual Understanding of Biomaterials, Revised 3rd Edition (Edited by Tsutomu Furuzono and Masahiro Okada, Clinical Engineering Library Series), in.
Advanced Biomaterials Leading the Age, Gakken Medical Shujunsha, (2018).
Size: B5 size, 164 pages, 3,200 yen (excluding tax), published on October 26, 2018.Click here for more details.