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最新の30件

【新聞】日刊工業新聞に生体用スーパーハイエントロピー合金の記事が掲載されました。

阪大、8元素混合成功 生体用ハイエントロピー合金 :日刊工業新聞、2024年2月29日、25面、 科学技術・大学欄トップ記事

日刊工業新聞 20240229 SHEA.png

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【論文】L-PBFで作製された純Crの組織やHIPによる摩耗への効果についての国際共同研究が、International Journal of Refractory Metals and Hard Materials(IF=3.6)へOA論文として掲載されました。

Asli Gunay Bulutsuz*, Buse Gulec, Ozkan Gokcekaya*, Johannes Gardstam, Takayoshi Nakano, Hakan Yilmazer:
An investigation over microstructure and HIP processing effects on wear performance of pure chromium parts fabricated by laser powder bed fusion,
International Journal of Refractory Metals and Hard Materials, 120, (2024), 106616, 1-10.
DOI: https://doi.org/10.1016/j.ijrmhm.2024.106616

論文はこちら
PDFこちら

Abstract
Chromium (Cr) and its alloys have long been valued for their exceptional properties, including corrosion resistance and high-temperature stability, rendering them indispensable in industrial applications such as chemical processing, energy production, and aerospace. However, due to the difficulties in Cr-based alloy manufacturing, there is a need for novel manufacturing methodologies. Additive Manufacturing (AM) emerges as a promising approach, particularly Laser Powder Bed Fusion (LPBF), which allows for intricate designs, reduced material waste, and simplified assembly. However, certain issues still need to be addressed, including defects like cracks and porosities in the manufactured parts. Post-processing techniques such as Hot Isostatic Pressing (HIP) have gained prominence for enhancing the material properties and quality of AM parts, including those produced using LPBF. HIP treatments are effective in eliminating internal pores, although some challenges remain, notably the presence of trapped argon and grain coarsening side effects of HIP process parameters. This study focuses on LPBF-processed pure chromium parts with crystallographic texture and investigates their properties after HIP treatment, including microstructure, hardness, and tribological performance. According to the obtained results: the HIP process reduced cracks, especially in the center region, but increased gaps in the side region. HIP also hindered grain realignment, limiting grain growth, and resulting in high HAGB density and low MUD values. Elevated HIP processing pressure negatively affected tribological performance due to increased grain size, and reduced hardness. This study, for the first time, realized the effect of HIP conditions on the microstructure and tribological performance of LPBF-processed pure Cr.

Keywords
Laser powder bed fusion; Pure Cr; Crystallographic texture; Hot isostatic pressing; Wear performance

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【行事】中野研の追いコンが開催されました。

中野研恒例の追いコンを実施しました。
卒業生には、皆からのメッセージや思い出の写真の入った手作りのアルバムとプレゼントが贈呈されました。
門出を祝うとともに寂しさも感じる行事でしたが、盛大に開催することができました。
卒業生の皆様には今後ともご活躍を期待しておりますし、気軽に立ち寄ってもらえたらと思います。
本当にお疲れ様でした。

LINE_ALBUM_追いコン_240223.jpg

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【論文】Materials Chemistry and Physics(IF=4.6)に世界で先駆けて(R≧2.0)の超ハイエントロピー合金(SHEA)を提案した論文が受理され、OAとして掲載される予定です。

Tadaaki Matsuzaka, Akira Hyakubu, Yong Seong Kim, Aira Matsugaki, Takeshi Nagase, Takuya Ishimoto, Ryosuke Ozasa, Hyoung Seop Kim, Tomoji Mizuguchi, Ozkan Gokcekaya, Takayoshi Nakano*:
Development of an equiatomic octonary TiNbTaZrMoHfWCr super high-entropy alloy for biomedical applications,
Materials Chemistry and Physics, (2024) accepted.

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【卒論】卒業論文発表会が行われました。

中野研の8名(内芝 旭祥君、菊川 泰地君、小坂 朋生君、清水 佑太君、中島 暢哉君、船奥 和真君、宮澤 啓太郎君、山野 大陸君)が卒業論文発表をしました。B4の皆さん、お疲れさまでした。

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【論文】生体用低弾性抗菌性Ti-Nb-Cu合金の開発に関する研究がMaterials Today Communications(IF=3.8)に掲載されました。

Qiang Li*, Qizhen Peng, Qi Huang, Mitsuo Niinomi, Takuya Ishimoto, Takayoshi Nakano:
Development and characterizations of low-modulus Ti-Nb-Cu alloys with enhanced antibacterial activities,
Materials Today Communications, 38, (2024), 108402, 1-8.
DOI: https://doi.org/10.1016/j.mtcomm.2024.108402
 
論文はこちら
PDFこちら
 
Abstract
Avoiding infection is a requirement for the long-term stability and safety of implants, but most Ti alloys for implantation hardly inhibit the bacterial proliferations. Cu works as a β stabilizer in Ti alloys, and Cu ion can kill bacteria. To obtain antibacterial activities in low-modulus Ti alloys, Ti-35Nb-(0, 1, 2, 3, 4)Cu (wt%) alloys were prepared by non-consumable arc melting following by homogenization, hot rolling, and solution treatment. They were then subjected to phase analysis, microstructure observation, tensile test and dynamic polarization. The cytotoxicity and antibacterial activities were finally evaluated. The results show that Cu stabilizes the β phase and inhibits the generation of α" phase during quenching. Ti-35 Nb and Ti-35Nb-1Cu consist of β and α" phases, and Ti-35Nb-(2, 3, 4)Cu alloys have a single β phase. The Ti-Nb-Cu alloys exhibit the Young's moduli ranging from 57 to 72 GPa. All the alloys show passivation behavior with a low passive current density. Cytotoxicity is hardly observed in the alloys. The antibacterial rates of Ti-35Nb-(1, 2, 3, 4)Cu alloys against E. coli are 62.8%, 68.9%, 70.9% and 73.2%, respectively, and the antibacterial rates against S. aureus are 63.4%, 69.7%, 72.8% and 74.7%, respectively. The developed β-type Ti-35Nb-4Cu alloy shows a relatively low Young's modulus and good antibacterial properties, and is a candidate for biomedical applications.
 
Keywords
Biomedical Ti alloys, Mechanical properties, Corrosion resistance, Cytotoxicity, Antibacterial properties

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【論文】生体用低弾性抗菌性Ti-Nb-Cu合金の開発に関する研究がMaterials Today Communications(IF=3.8)に受理されました。

Qiang Li*, Qizhen Peng, Qi Huang, Mitsuo Niinomi, Takuya Ishimoto, Takayoshi Nakano:
Development and characterizations of low-modulus Ti-Nb-Cu alloys with enhanced antibacterial activities,
Materials Today Communications, (2024), in press.

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【修論】修士論文発表会が行われました。

中野研の5名(大原 秀真君、木澤 雄太君、北上 真幸君、丹羽 陽一朗君、百歩 明君)が修士論文の発表をしました。M2の皆さん、お疲れ様でした。

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【論文】L-PBFで作製された純Crの組織やHIPによる摩耗への効果についての国際共同研究が、International Journal of Refractory Metals and Hard Materials(IF=3.6)へ受理されました。

Asli Gunay Bulutsuz*, Buse Gulec, Ozkan Gokcekaya*, Johannes Gardstam, Takayoshi Nakano, Hakan Yilmazer:
An investigation over microstructure and HIP processing effects on wear performance of pure chromium parts fabricated by laser powder bed fusion,
International Journal of Refractory Metals and Hard Materials, (2024), in press.

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【書籍】中野先生が分担執筆した『傾斜機能材料ハンドブック』が2024年2月15日に発刊されます。

萩原幸司、徳永透子、中野貴由(分担):
第II編 第1章 第2節 超高温耐用複相シリサイド合金の開発、
傾斜機能材料ハンドブック、株式会社エヌ・ティー・エス、pp152-165、2024年2月15日発刊、ISBN: 978-4-86043-776-3
 
パンフレットはこちら

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【招待講演】中野先生が熱処理技術セミナーで金属3Dプリンターに関する講演を行いました。

中野貴由:
金属3Dプリンティングによる集合組織制御と高機能化~近未来の新設計に向けて~、
熱処理技術セミナー(2023年度第4回)-熱処理応用講座―、粉末會舘(東京)、2024年1月29日10:00~11:30.

プログラムはこちら
講演内容はこちら

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【論文】Bone誌(IF=4.1)に骨密度よりも、骨基質の配向性が骨の力学機能適応に強く効くこと示した論文がOA論文として掲載されました。

Jun Wang, Takuya Ishimoto, Tadaaki Matsuzaka, Aira Matsugaki, Ryosuke Ozasa, Takuya Matsumoto, Mikako Hayashi, Hyoung Seop Kim, Takayoshi Nakano*:
Adaptive Enhancement of Apatite Crystal Orientation and Young's Modulus Under Elevated Load in Rat Ulnar Cortical Bone,
Bone, 181, (2024), 117024: 1-10.
https://doi.org/10.1016/j.bone.2024.117024

論文はこちら
PDFこちら

Abstract
Functional adaptation refers to the active modification of bone structure according to the mechanical loads applied daily to maintain its mechanical integrity and adapt to the environment. Functional adaptation relates to bone mass, bone mineral density (BMD), and bone morphology (e.g., trabecular bone architecture). In this study, we discovered for the first time that another form of bone functional adaptation of a cortical bone involves a change in bone quality determined by the preferential orientation of apatite nano-crystallite, a key component of the bone. An in vivo rat ulnar axial loading model was adopted, to which a 3-15 N compressive load was applied, resulting in approximately 440-3200 μɛ of compression in the bone surface. In the loaded ulnae, the degree of preferential apatite c-axis orientation along the ulnar long axis increased in a dose-dependent manner up to 13 N, whereas the increase in BMD was not dose-dependent. The Young's modulus along the same direction was enhanced as a function of the degree of apatite orientation. This finding indicates that bone has a mechanism that modifies the directionality (anisotropy) of its microstructure, strengthening itself specifically in the loaded direction. BMD, a scalar quantity, does not allow for load-direction-specific strengthening. Functional adaptation through changes in apatite orientation is an excellent strategy for bones to efficiently change their strength in response to external loading, which is mostly anisotropic.

Keywords
Functional adaptation; Bone strength; Apatite orientation; Bone quality: In vivo loading

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【論文】密着性を向上させたZnコーティングによるTiの抗菌性向上に関する国際共同研究がMaterials Today Communications(IF=3.8)に掲載されました。

Ming Li, Qiang Li*, Jiawei Yang, Mitsuo Niinomi, Takayoshi Nakano:
Preparation and Antibacterial Activity of Zn Coating on Pure Ti with Enhanced Adhesion,
Materials Today Communications, 38, (2024), 1-10
https://doi.org/10.1016/j.mtcomm.2024.108149

論文はこちら
PDFこちら

Abstract
A titania nanotubes layer was prepared as an intermediate layer on pure Ti via anodic oxidation, and subsequently, a Zn-containing coating was electrochemically deposited. The influence of the deposition parameters on the Zn content was studied using an orthogonal experiment. The obtained coatings were characterized using scanning electron microscopy, energy-dispersive spectroscopy, X-ray diffraction, and X-ray photoelectron spectroscopy, and their adhesion was measured using a scratch test. The deposition time had the greatest effect on the Zn content of the electrodeposited samples, whereas the deposition temperature had the smallest effect. After the electrodeposition, Zn was uniformly distributed on the surface and existed mainly as a simple substance. The adhesion was only 10.9 N in the Zn-free sample; it increased with increasing Zn content of the samples, and reached a maximum value of 22.4 N in the sample with a Zn content of approximately 16%. The samples with Zn-containing coatings exhibited strong antibacterial effects against E. coli and S. aureus, and the antibacterial effect increased with increasing Zn content. Cell viability was above 80%, indicating that the Zn-containing coating is a good candidate as an antibacterial coating for biomedical applications.

Keywords
Zn-containing coating; Electrochemical deposition; Orthogonal experiment; Adhesion; Antibacterial property; Pure Ti

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【書籍】中野先生が分担執筆した書籍「新・力を診る~臨床と研究の接点」が出版されました。

中野貴由(分担執筆):新・力を診る、(編著)市川哲夫、森本達也、熊谷真一医歯薬出版株式会社、2024年1月25日出版
ISBN978-4-263-46177-8
澤瀬隆、黒嶋伸一郎、中野貴由:骨のバイオロジー、pp.76~82.

PDFこちら

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【新聞】日刊工業新聞に配向化による骨強度上昇に関する記事が掲載されました。

強度上昇、配向性が寄与―生体骨への負荷大きいほど高く 阪大など発見:日刊工業新聞、2024年1月25日、27面、科学技術・大学欄トップ記事

2024.01.25日刊工業新聞.jpg

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【論文】Bone誌(IF=4.1)に骨密度よりも、骨基質の配向性が骨の力学機能適応に強く効くこと示した論文が受理され、OA論文として掲載されます。

Jun Wang, Takuya Ishimoto, Tadaaki Matsuzaka, Aira Matsugaki, Ryosuke Ozasa, Takuya Matsumoto, Mikako Hayashi, Hyoung Seop Kim, Takayoshi Nakano*:
Adaptive Enhancement of Apatite Crystal Orientation and Young's Modulus Under Elevated Load in Rat Ulnar Cortical Bone,
Bone, (2024), in press.

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【論文】The International Journal of Advanced Manufacturing Technology(IF=3.4)に論文がOAとして掲載されました。

Ozkan Gokcekaya*, Ali Günen, Ferhat Ceritbinmez, Abdollah Bahador, Takayoshi Nakano, Melik Çetin:
Wire-EDM performance and surface integrity of Inconel 718 with unique microstructural features fabricated by laser powder bed fusion,
The International Journal of Advanced Manufacturing Technology, (2024), 1-16
https://doi.org/10.1007/s00170-023-12924-7
 
論文はこちら
PDFこちら

Abstract
Inconel 718 alloy is difficult to machine using conventional methods due to its physical properties. Thereby, additive manufacturing (AM) of IN718 components with near-net shapes has been extensively studied. Even though AM processes provide shape and size accuracy, there is still the need for the machining of the AM-processed components to achieve the final shape of a component. Laser powder bed fusion (LPBF) has been successfully utilized to fabricate near-net shape IN718 components; moreover, the microstructure of LPBF-IN718 was unique owing to the AM processing, resulting in differences in grain size, grain boundary characteristics, and grain orientations. Furthermore, these microstructural characteristics are expected to alter the machining performance of IN718. Therefore, this study investigated the wire electro-discharge machining (WEDM) performance of LPBF-718 samples compared to wrought IN718 while focusing on the unique microstructure characteristics of LPBF-IN718 samples (lamella, single-crystal, ploy-crystal). Three different cutting strategies (rough, semi-finish, and finish) were implemented to understand the performance of the multi-pass cutting phenomenon and its effect on the surface of IN718. For all samples, rough (single pass) cutting displayed high roughness, while finish (three passes) cutting exhibited good surface quality. Compositional analyses on the machined surface showed debris formation including Zn and Cu-containing recast material, indicating wire erosion. The surface of single-crystal LPBF-IN718 after the WEDM process was smooth owing to its large grain size and less amount of grain boundary, resulting in slow cutting speed but a good surface finish. Thus, this study, for the first time, investigated the effect of unique microstructural characteristics of LPBF-fabricated IN718 on WEDM performance and machined surface quality.

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【論文】密着性を向上させたZnコーティングによるTiの抗菌性向上に関する国際共同研究がMaterials Today Communications(IF=3.8)に受理されました。

Ming Li, Qiang Li*, Jiawei Yang, Mitsuo Niinomi, Takayoshi Nakano:
Preparation and Antibacterial Activity of Zn Coating on Pure Ti with Enhanced Adhesion,
Materials Today Communications, (2024), in press.

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【MMI】中野先生がMetals and Materials International (MMI)のeditorial committee memberになりました。

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【特別講演会】金子 真 先生(名城大教授・大阪大名誉教授)に特別講演会(第2回)を行っていただきました。

名城大学大学院理工学研究科 教授
大阪大学 名誉教授
 金子 真 先生
タイトルその1:Biomimetic(生き物から学ぶ)
タイトルその2:ハイパーヒューマン、Beyond Human Technology
大阪大学材料系R2棟マテリアル会議室、2024年1月12日

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【解説】ChemCatChemにAM触媒に関する解説が掲載されました。

Hyo-Jin Kim, Kohsuke Mori, Takayoshi Nakano, Hromi Yamashita:
Advances in Metal 3D Printing Technology for Tailored Self-Catalytic Reactor Design,
ChemCatChem, (2023), 1-7
https://doi.org/10.1002/cctc.202301380

論文はこちら
PDFこちら

Abstract
Metal 3D printing is revolutionizing the industry by enabling rapid and cost-effective production of complex metal 3D products with intricate geometries, attracting significant attention in recent years. Particularly, metal 3D-printed catalysts have emerged as a cutting-edge fusion technology that serves as both catalysts and reactors, referred to as self-catalytic reactors (SCRs). Therefore, this concept article aims to introduce the recent advancements in metal 3D printing technology in the catalyst and reactor field, and illustrate the various aspects for the rational design of self-catalytic reactors.

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【論文】レーザ積層造形法で作製したマイクロ溝が間葉系幹細胞の分化を促進することを示した論文が、International Journal of Bioprinting (IF=8.4)にOA論文として掲載されました。

Aira Matsugaki, Tadaaki Matsuzaka, Toko Mori, Mitsuka Saito, Kazuma Funaoku, Riku Yamano, Ozkan Gokcekaya, Ryosuke Ozasa, Takayoshi Nakano:
PBF-LB fabrication of microgrooves for induction of osteogenic differentiation of human mesenchymal stem cells,
International Journal of Bioprinting, 10(1), (2024), 406-416
https://doi.org/10.36922/ijb.1425

論文はこちら
PDFこちら
 
Abstract
Stem cell differentiation has important implications for biomedical device design and tissue engineering. Recently, inherent material properties, including surface chemistry, stiffness, and topography, have been found to influence stem cell fate. Among these, surface topography is a key regulator of stem cells in contact with materials. The most important aspect of ideal bone tissue engineering is to control the organization of the bone extracellular matrix with fully differentiated osteoblasts. Here, we found that laser powder bed fusion (PBF-LB)-fabricated grooved surface inspired by the microstructure of bone, which induced human mesenchymal stem cell (hMSC) differentiation into the osteogenic lineage without any differentiation supplements. The periodic grooved structure was fabricated by PBF-LB which induced cell elongation facilitated by cytoskeletal tension along the grooves. This resulted in the upregulation of osteogenesis via Runx2 expression. The aligned hMSCs successfully differentiated into osteoblasts and further organized the bone mimeticoriented extracellular matrix microstructure. Our results indicate that metal additive manufacturing technology has a great advantage in controlling stem cell fate into the osteogenic lineage, and in the construction of bone-mimetic microstructural organization. Our findings on material-induced stem cell differentiation under standard cell culture conditions open new avenues for the development of medical devices that realize the desired tissue regeneration mediated by regulated stem cell functions.
 
Keywords: Additive manufacturing; Laser powder bed fusion; Mesenchymal stem cells; Osteogenic differentiation; Bone microstructure

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【特別講演会】倉重 英樹 様(シグマクシス会長)に特別講演会を行っていただきました。

株式会社シグマクシス・ホールディングス ファウンダー名誉会長
 倉重 英樹 様
講演タイトル:「人的資本投資の意味するところ」
・社会の大きな変化(グローバリゼーションの現状、日本の現状等)
・デジタルの時代にどうビジネスを展開するか(三つの「X (MX, DX, SX)」について等)
大阪大学センテラスサロン、2024年1月9日
 
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講演の様子
 IMG_3802.jpgのサムネイル画像のサムネイル画像会場の様子
 
IMG_3810.jpgのサムネイル画像集合写真(最前列中央が倉重英樹 ファウンダー名誉会長、左隣が前川篤 シニアフェロー)

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【論文】The International Journal of Advanced Manufacturing Technology(IF=3.4)に論文が受理されました。

Ozkan Gokcekaya*, Ali Günen, Ferhat Ceritbinmez, Abdollah Bahador, Takayoshi Nakano, Melik Çetin:
Wire-EDM performance and surface integrity of Inconel 718 with unique microstructural features fabricated by laser powder bed fusion,
The International Journal of Advanced Manufacturing Technology, (2024) in press.

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【論文】Journal of the Mechanical Behavior of Biomedical Materials(IF=3.9)に上海科学技術大学、新家先生とのヨウドの表面析出による感染抑制に関する共同研究の成果が掲載されました。

Qiang Li*, Shuaishuai Li, Hao Sun, Mitsuo Niinomi, Takayoshi Nakano:
Preparation and Characterizations of Antibacterial Iodine-containing Coatings on Pure Ti,
Journal of the Mechanical Behavior of Biomedical Materials, 151, (2024), 106366, 1-8.
https://doi.org/10.1016/j.jmbbm.2023.106366

論文はこちら
PDFこちら

Abstract
Iodine-containing coatings were prepared on pure Ti surfaces via electrochemical deposition to enhance their antibacterial properties. The factors influencing iodine content were analyzed using an orthogonal experiment. The electrochemically deposited samples were characterized using scanning electron microscopy with energy dispersive spectroscopy and X-ray photoelectron spectroscopy, and their antibacterial properties and cytotoxicity were evaluated. The results showed that changing the deposition time is an effective way to control the iodine content. The iodine content, coating thickness, and adhesion of the samples increased with deposition time. Iodine in the coatings mainly exists in three forms, which are I2, I3−, and pentavalent iodine. For samples with iodine-containing coatings, the antibacterial ratios against E. coli and S. aureus were greater than 90% and increased with increasing iodine content. Although the samples with iodine-containing coatings showed some inhibition of the proliferation of MC3T3-E1 cells, the cell viabilities were all higher than 80%, suggesting that iodine-containing coatings are biosafe.

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【お見舞い】令和6年能登半島地震で被災された方に心よりお見舞い申し上げます。研究室、さらには関係者にも、北陸地方出身者・居住者がおり、被災状況を確認しているところです。何かできることがあれば、至急、研究室にご連絡ください。

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大阪大学ローバース育成会のHPを公開いたしました。中野先生が育成会長を務めます。大阪大学ローバースは2023年4月1日に「日本ボーイスカウト大阪連盟ほくせつ地区豊中第28団」として、正式登録されました。さらに大阪大学本部学生部のもとで、万博の成功のためにSDGs活動を行っていきます。大阪大学ローバース育成会はボーイスカウト連盟の規定に沿って、大阪大学ローバースの学生を資金面から支援する団体です。

HPはこちら
 
【【育成会員募集】】
「大阪大学ローバースの活動を支援し、スカウトの健全な育成を後援する」という育成会の目的に賛同し、資金などを援助していただく育成会員を募集しています
育成会員は以下の3つがあります。
 
●正会員
個人を対象にしたものです。年額8,000円を支援いただきます。
 
●協力会員
個人を対象にしたものです。年額1口5,000円(0口以上)を支援いただきます。会費は払えないけれど、大阪大学ローバースを応援したいという方や、本会の目的に賛同いただける方は、是非こちらで会員となっていただけると幸いです。
 
●賛助会員
企業向けのものです。賛助金として年額1口10,000円(1口以上)を支援いただきます。
 
大阪大学内外で是非ご支援をお願いできればと存じます。
HPより、お申し込みを是非お願いいたします。
 
IMG_3138.jpg
大阪大学ローバースの豊中28団としてのお披露目会(2023年10月14日)に主賓として田中副学長に祝辞をいただきました。

大阪大学ローバース育成会長・中野貴由
大阪大学ローバース副育成会長・坂本繁

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【解説】まてりあ1月号にJST-Crest(ナノ力学)の記事が掲載されました。

中野貴由*、石本卓也、松垣あいら、小笹良輔、ゴクチェカヤオズカン、安田弘行、趙研、小泉雄一郎、奥川将行、吉矢真人、藤井進、多根正和、三好英輔、東野昭太:
金属3D プリンティングの特異界面形成によるカスタム力学機能制御学の構築 ~階層化異方性骨組織に学びつつ~、
まてりあ、63[1], (2024), pp.36-41

解説はこちら
中野GのPDFはこちら
阿部GのPDFはこちら
眞山GのPDFはこちら
まてりあ1月号のPDFはこちら

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明けましておめでとうございます。今年も中野研一同精進していきますので、ご支援ご指導のほどよろしくお願い申し上げます。

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【論文】Journal of Bone and Mineral Metabolism(IF=3.3)に浜松医科大の松山先生のグループとの共同研究の成果がOAとして出版され、ページが付与されました。Cckbr欠損マウスにおけるアパタイト配向性の低下を解明しています。

Yuki Mihara, Takuya Ishimoto, Ryosuke Ozasa, Takao Omura, Yu Yamato, Tomohiro Yamada, Ayako Okamoto, Yukihiro Matsuyama*, Takayoshi Nakano*:
Deterioration of apatite orientation in the cholecystokinin B receptor gene (Cckbr) deficient mouse femurs,
Journal of Bone and Mineral Metabolism, 41, (2023), 752-759.
https://doi.org/10.1007/s00774-023-01460-9

論文はこちら
論文のPDFはこちら

Abstract
Introduction
The discrepancy between bone mineral density (BMD), the gold standard for bone assessment, and bone strength is a constraint in diagnosing bone function and determining treatment strategies for several bone diseases. Gastric hypochlorhydria induced by clinically used proton pump inhibitor (PPI) therapy indicates a discordance between changes in BMD and bone strength. Here, we used Cckbr-deficient mice with gastric hypochlorhydria to examine the effect of gastric hypochlorhydria on bone mass, BMD, and preferential orientation of the apatite crystallites, which is a strong indicator of bone strength.
Materials and methods
Cckbr-deficient mice were created, and their femurs were analyzed for BMD and preferential orientation of the apatite c-axis along the femoral long axis.
Results
Cckbr-deficient mouse femurs displayed a slight osteoporotic bone loss at 18 weeks of age; however, BMD was comparable to that of wild-type mice. In contrast, apatite orientation in the femur mid-shaft significantly decreased from 9 to 18 weeks. To the best of our knowledge, this is the first report demonstrating the deterioration of apatite orientation in the bones of Cckbr-deficient mice.
Conclusion
Lesions in Cckbr-deficient mice occurred earlier in apatite orientation than in bone mass. Hence, bone apatite orientation may be a promising method for detecting hypochlorhydria-induced osteoporosis caused by PPI treatment and warrants urgent clinical applications.

Keywords
Cckbr-defcient mice · Bone quality · Apatite orientation · Hypochlorhydria · Bone evaluation

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