What's New
2018（January－June）
-
2018.6.11
-
2018.6.1
-
2018.4.25
-
2018.4.20
-
2018.4.11
-
2018.4.8
-
2018.3.23
-
2018.3.21
-
2018.3.16
-
2018.2.14
-
2018.2.8
-
2018.2.5
-
2018.2.3
-
2018.1.30
-
2018.1.26
-
2018.1.23
-
2018.1.23
-
2018.1.17
-
2018.1.3
-
2018.6.11
At the 38th Annual Meeting of the Japanese Society for Bone Morphometry, Mr. Ozasa (D3) was awarded the Academic Encouragement Award and Mr. Nakanishi (M2) was awarded the Young Investigator Award.
Ryosuke Ozasa, Kyohei Sasaki, and Takayoshi Nakano:
Contribution of Apolipoprotein E to the Regulation Mechanism of Bone Orientation,
the 38th Annual Meeting of the Japanese Society for Bone Morphometry Academic Encouragement Award, Osaka International House, June 23, 2018Yohei Nakanishi, Aira Matsugaki, Takayoshi Nakano:
Mechanism of osteoblast and bone matrix orientation by nano-periodic surface structures,
the 38th Annual Meeting of the Japanese Society for Bone Morphometry, Osaka International House, June 23, 2018.
-
2018.6.1
A commentary on "Phosphate Invert Glasses in Biomaterials" has been published in Phosphorus Letter.
Seongho Lee, Takayoshi Nakano:
Phosphate Invert Glasses for Biomedical Application,
Phosphorus Letter, No.92 [6], (2018), 20-31.Click here for this PDF.
-
2018.4.25
Collaborative research results on oxygen doping of Ti were published in Materials Transactions.
Qiang Li, Dong Ma, Junjie Li, Mitsuo Niinomi, Masaaki Nakai, Yuichiro Koizumi, Daixiu Wei, Tomoyuki Kakeshita, Takayoshi Nakano, Akihiko Chiba, Kai Zhou, Deng Pan:
Low Young’s Modulus Ti-Nb-O with High Strength and Good Plasticity,
Materials Transactions,59 [5], (2018) pp.858-860.Abstract
Oxygen was added to Ti–38Nb (mass%) alloys to improve their mechanical properties. Ti–38Nb–xO (x = 0.13, 0.24, 0.46, mass%) alloys were prepared by arc melting, and subsequently subjected to homogenization, hot rolling, and solution treatment. It was found that adding oxygen suppresses the martensite transformation and exhibits strong solution strengthening effect. Single β phase is obtained in Ti–38Nb–0.24O, whereas Ti–38Nb–0.13O is composed of both α′′ and β phases. Both alloys exhibit double yielding phenomena during tension, indicating a stress-induced martensitic transformation. Ti–38Nb–0.46O exhibits a non-linear deformation, a low Young’s modulus of 62 GPa, high tensile strength up to 780 MPa, and elongation around 23%, which are promising characteristics for biomedical applications.
Click here for this paper.
-
2018.4.20
A paper on biological high-entropy alloys discovered in our laboratory has been published in the Journal of Alloys and Compounds (JALCOM) as an open access journal.
Takeshi Nagasea, Mitsuharu Todai, Takao Hori, Takayoshi Nakano:
Microstructure of equiatomic and non-equiatomic Ti-Nb-Ta-Zr-Mo high-entropy alloys for metallic biomaterials,
Journal of Alloys and Compounds (JALCOM), (2018), in press.
doi.org/10.1016/j.jallcom.2018.04.082Abstract
Athermal ω-phase transformation and the appearance of the lattice modulation in Ti-28Nb-xAl alloys were investigated by electrical resistivity measurements and transmission electron microscopy (TEM) observations. As a result, the athermal ω-phase is gradually suppressed with increasing Al content. In addition, the lattice modulation is also observed in Ti-28Nb-xAl alloys (0 ≤ x ≤ 7, in at.%) because of the transverse wave with a propagation vector of q = 1/2[ζζ¯0]∗ and displacement in [110]. These results imply that the ω-phase can be controlled by addition of the Al content in Ti-Nb alloys, leading to the development of low Young's modulus β-phase Ti biomedical alloys single crystal
Click here for this paper.
-
2018.4.11
An article introducing the results of Nakano Lab's research was posted on the website.
Click here for this article.
-
2018.4.8
A collaborative research paper with Narushima Laboratory, Tohoku University on deformation and corrosion of Co-Cr alloys due to unique microstructure formation by heat treatment has been published in Metallurgical and Materials Transactions A.
Kosuke Ueki, Kyosuke Ueda, Masaaki Nakai, Takayoshi Nakano, Takayuki Narushima:
Microstructural Changes During Plastic Deformation and Corrosion Properties of Biomedical Co-20Cr-15W-10Ni Alloy Heat-Treated at 873 K,
Metallurgical and Materials Transactions A, (2018) in press.
doi.org/10.1007/s11661-018-4597-0Click here for this paper.
-
2018.3.23
Dr. Nakano was awarded the 68th Japan Institute of Metals and Materials Metallography Award.
Koji Hagiwara, Takateru Ikenishi, Takayoshi Nakano:
Development of an unusual "cross-lamellar microstructure" in C40/C11b ultra-high temperature heat-resistant multiphase silicide alloys,
The 68th Japan Institute of Metals and Materials Metallography Award ([Division 2] Scanning Electron Microscopy Section "Award of Excellence"), Chiba Institute of Technology, March 19, 2018. -
2018.3.21
Mr. Hori, who is currently an M2 student at Nakano Lab, received the Osaka University Industrial Association Award.
Takao Hori :
Development of novel bcc-type high-entropy alloys for biological applications -
2018.3.16
An article about our laboratory's research was published in the March issue of Monthly Municipal Solutions (pages 69-71).
This article was written by Takeshi Hayashi of the Nikkan Kogyo Shimbun, and introduces the research of the Nakano Research Institute in the article "Implants open new horizons in bone fracture treatment and tooth reconstruction".
Click here for more details.
-
2018.2.14
Our collaborative research with Professor Takuya Matsumoto, Graduate School of Medical and Dental Sciences, Okayama University, which discovered a new bone formation mechanism in the early stage of calcification in secondary ossification, has been publish
(1) Emilio Satoshi Hara, Masahiro Okada, Noriyuki Nagaoka, Takako Hattori, Takuo Kuboki, Takayoshi Nakano, Takuya Matsumoto:
Bioinspired mineralization using chondrocyte membrane nanofragments,
ACS Biomaterials Science & Engineering, 4 [2] ,(2018) pp.617-625.Abstract
Biomineralization involves complex processes and interactions between organic and inorganic matters, which are controlled in part by the cells. The objectives of this study were, first, to perform a systematic and ultrastructural investigation of the initial mineral formation during secondary ossification center of mouse femur based on material science and biology viewpoint, and then develop novel biomaterials for mineralization based on the in vivo findings. First, we identified the very initial mineral deposition at postnatal day 5 (P5) at the medial side of femur epiphysis by nanocomputed tomography. Initial minerals were found in the surroundings of hypertrophic chondrocytes. Interestingly, histological and immunohistochemical analyses showed that initial mineralization until P6 was based on chondrocyte activity only, i.e., it occurred in the absence of osteoblasts. Moreover, electron microscopy-based ultrastructural analysis showed that cell-secreted matrix vesicles were absent in the early steps of osteoblast-independent endochondral ossification. Instead, chondrocyte membrane nanofragments were found in the fibrous matrix surrounding the hypertrophic chondrocytes. EDS analysis and electron diffraction study indicated that cell membrane nanofragments were not mineralized material, and could be the nucleation site for the newly formed calcospherites. The phospholipids in the cell membrane nanofragments could be a source of phosphate for subsequent calcium phosphate formation, which initially was amorphous, and later transformed into apatite crystals. Finally, artificial cell nanofragments were synthesized from ATDC5 chondrogenic cells, and in vitro assays showed that these nanofragments could promote mineral formation. Taken together, these results indicated that cell membrane nanofragments were the nucleation site for mineral formation, and could potentially be used as material for manipulation of biomineralization.Click here for this paper.
(2) Emilio Satoshi Hara, Masahiro Okada, Noriyuki Nagaoka, Takako Hattori, Takuo Kuboki, Takayoshi Nakano, Takuya Matsumoto:
Chondrocyte burst promotes space for mineral expansion,
Integrative Biology, 10 ,(2018) pp.57-66.Abstract
Analysis of tissue development from multidisciplinary approaches can result in more integrative biological findings, and can eventually allow the development of more effective bioengineering methods. In this study, we analyzed the initial steps of mineral formation during secondary ossification of mouse femur based on biological and bioengineering approaches. We first found that some chondrocytes burst near the mineralized area. External factors that could trigger chondrocyte burst were then investigated. Chondrocyte burst was shown to be modulated by mechanical and osmotic pressure. A hypotonic solution, as well as mechanical stress, significantly induced chondrocyte burst. We further hypothesized that chondrocyte burst could be associated with space-making for mineral expansion. In fact, ex vivo culture of femur epiphysis in hypotonic conditions, or under mechanical pressure, enhanced mineral formation, compared to normal culture conditions. Additionally, the effect of mechanical pressure on bone formation in vivo was investigated by immobilization of mouse lower limbs to decrease the body pressure onto the joints. The results showed that limb immobilization suppressed bone formation. Together, these results suggest chondrocyte burst as a novel fate of chondrocytes, and that manipulation of chondrocyte burst with external mechano-chemical stimuli could be an additional approach for cartilage and bone tissue engineering.Click here for this paper.
-
2018.2.8
Our laboratory's commentary on bone and osteoarticular medical devices using metal 3D printers was published in Clinical Orthopedics.
Takayoshi Nakano, Takuya Ishimoto, Ryosuke Ozasa, Eiji Fukuda:
Advanced status of metal 3D printing : Toward application to bone and osteoarticular field,
Clinical Orthopaedics, Vol. 53 [2] (2018), pp. 137-144.Click here for this PDF.
-
2018.2.5
A study on fatigue properties of TiAl with special layers formed by electron beam additive manufacturing (EBM) has been published in Intermetallics (Elsevier).
Ken Cho, Ryota Kobayashi, Jong Yeong Oh, Hiroyuki Y. Yasuda, Mitsuharu Todai, Takayoshi Nakano, Ayako Ikeda, Minoru Ueda, Masao Takeyama:
Influence of unique layered microstructure on fatigue properties of Ti-48Al2Cr-2Nb alloys fabricated by electron beam melting,
Intermetallics, 95, (2018), 1-10.Abstract
The influence of a unique layered microstructure consisting of duplex-like region and equiaxed γ grain layers (γ bands) on the fatigue properties of Ti-48Al-2Cr-2Nb alloy bars fabricated by electron beam melting (EBM) was investigated at room temperature (RT) and 1023 K focusing on the angle (θ) between the building direction and cylinder (loading) axis. We found for the first time the fatigue strengths of the alloy bars with the layered microstructure depend strongly on the angle θ. Particularly, the fatigue strength of the alloy bars fabricated at θ = 45° is comparable to that of the hot isostatic pressing (HIP) treated cast alloys, even without HIP treatment. We also found the alloy bars fabricated at θ = 0° and 45° exhibit high fatigue strengths in the low-cycle fatigue life region at 1023 K similar to θ = 45° alloy bars at RT. These high fatigue strengths are caused by inhibition of the brittle main crack initiation by stress relaxation due to shear deformation at the γ bands and large plasticity of the alloys. These findings indicate that the alloys fabricated by EBM at θ = 45° with the unique layered microstructure have a great potential for aerospace and automobile applications. -
2018.2.3
A paper on the analysis of substrate orientation in vascular mesomembranes has been published early in the Journal of the Japan Institute of Metals and Materials.
Ryosuke Ozasa, Takeru Nagaishi, Daisuke Yamazaki, Aira Matsugaki, Machiko Kanzaki, Toru Kuratani, Eiichi Morii, Yasushi Sakata, Takayoshi Nakano*:
Establishment of a quantitative analysis method for elucidating collagen/elastin fibril orientation in vascular tunica media,
Journal of the Japan Institute of Metals and Materials, 82 [3], (2018),
DOI:10. 2320/jinstmet.J2017060.Click here for this paper.
-
2018.1.30
A paper proving that long-term cigarette smoking with Keio University School of Medicine has a negative effect on bone quality was published in PLOS ONE as an open access journal.
Mamoru Sasaki, Shotaro Chubachi, Naofumi Kameyama, Minako Sato, Mizuha Haraguchi, Masaki Miyazaki, Saeko Takahashi, Takayoshi Nakano, Yukiko Kuroda, Tomoko Betsuyaku, Koichi Matsuo:
Effects of long-term cigarette smoke exposure on bone metabolism, structure, and quality in a mouse model of emphysema,
PLOS ONE, 13(1) (2018), e0191611.Abstract
Smoking is a common risk factor for both chronic obstructive pulmonary disease (COPD) and osteoporosis. In patients with COPD, severe emphysema is a risk factor for vertebral fracture; however, the effects of smoking or emphysema on bone health remain largely unknown. We report bone deterioration in a mouse model of emphysema induced by nose-only cigarette smoke (CS) exposure. Unexpectedly, short-term exposure for 4-weeks decreased bone turnover and increased bone volume in mice. However, prolonged exposure for 20- and 40-weeks reversed the effects from suppression to promotion of bone resorption. This long-term CS exposure increased osteoclast number and impaired bone growth, while it increased bone volume. Strikingly, long-term CS exposure deteriorated bone quality of the lumbar vertebrae as illustrated by disorientation of collagen fibers and the biological apatite c-axis. This animal model may provide a better understanding of the mechanisms underlying the deterioration of bone quality in pulmonary emphysema caused by smoking.Click here for this paper.
-
2018.1.26
Mr. Sugimoto (M1) won the Best Poster Award at the 2nd Materials Science and Engineering Conference in 2018.
Shota Sugimoto, Takuya Ishimoto, Aira Matsugaki, Kiyoshi Yoshida, Dai Otsuki, Hideki Yoshikawa, and Takayoshi Nakano:
A novel bone regeneration method to promote orientation and mechanical function recovery of regenerated bone. -
2018.1.23
An article on the results of the joint research with Hokkaido Medical Center and Tokyo Medical and Dental University to establish a method to evaluate bone health after spinal implant placement was published in the Nikkan Kogyo Shimbun on January 23.
Click here for this article.
-
2018.1.23
An article on the discovery of a new bone formation mechanism in the early stage of calcification in secondary ossification was published in the Asahi Shimbun on January 18 and the Nikkan Kogyo Shimbun on January 22.
Click here for these articles.
-
2018.1.17
A comprehensive paper of our laboratory was published in "Japanese Journal of Polymer Science and Technology".
Aira Matsugaki, Takayoshi Nakano :
Induction of Bone Orientation Based on Cell Regulation by Medical Materials,
Japanese Journal of Polymer Science and Technology, Special Issue on Medical Polymers, Vol. 75, (2018), pp. 164-173.Click here for this paper.
-
2018.1.3
The 70th anniversary issue of "Production and Technology" contains an article on the high-tech promotion seminar organized by Prof. Nakano.
Takayoshi Nakano :
Construction of a 3D printer base in Kansai and creation of modeling objects by shape and material control.
Production and Technology, 70 [1], (2018), pp.19-26.Click here for the 70th anniversary issue of "Production and Technology".
Click here for the articleArticle Summary
Special Feature 2 (High-tech Promotion Seminar)
Revolution of "Manufacturing" by 3D Printer - What can be made and how? -
Introduction of lecturer:Nobuto Imanaka
Opening speech:Takayoshi Nakano
Establishment of a 3D printer base in Kansai and creation of modeling objects by shape and material control:Takayoshi Nakano
Trends of 3D manufacturing in Kansai companies - Changes brought by AM technology -:Takashi Matsushita
Fabrication of metal and ceramic structures by micro-particle paste photolithography:Toshihide Kirihara
Development of Medical Products by Electron Beam Additive Manufacturing :Takayuki Inoue
New Production Technology for Transportation Equipment and Energy Equipment by 3D Manufacturing :Kenichiro Igashira
Application of 3D printing technology in Panasonic and its future prospects :Masatoshi Teranishi